CBDA is found in the cannabis plant, primarily in its resinous trichome glands, where it begins as cannabigerol acid (CBGA) and undergoes an enzymatic reaction to become CBDA. Cannabidiolic acid (CBDA) is a cannabinoid with promising health benefits.
CBDA has no psychotropic effects and has been shown to have stronger activation of 5-HT1A serotonin receptors compared to CBD.
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What is the cannabinoid CBD and what is CBDA?
The origin of CBDA is essential to understanding its effects on the body.
Here is a description of its chemical composition profile:
Chemical Name: Cannabidiolic acid
Molecular Formula: C22H30O4
Molecular Weight: 358.47 g/mol
CBDA is a naturally occurring compound that is found in raw cannabis plants. When heated or over time, CBDA is converted into CBD. According to recent research, CBDA may have the potential to become a powerful tool for improving health.
To better understand what CBDA is, it’s important to take a step back and recall the different types of cannabinoids.
Cannabinoids are the active compounds in the cannabis plant that interact with the endocannabinoid system, a network of cannabinoid receptors located throughout the body. The two best known cannabinoids are THC and CBD, but there are many other cannabinoids in the plant.
Cannabinoids are most commonly found in the resinous glands of the buds and leaves of plants.
They are formed from the chemical reaction between geranyl pyrophosphate and olivetolic acid, which produces cannabigerolic acid (CBGA). CBGA is the ‘parent cannabinoid’ that is converted into three of the most common cannabinoids found in cannabis plants: tetrahydrocannabinolic acid (THCA), cannabichromonic acid (CBCA) and CBDA.
When cannabis is heated, dried or exposed to light, the acid molecules undergo a process called decarboxylation, which converts them to their active forms.
Although THCA, CBCA and CBDA are primarly present in the plant in acid form, they are decarboxylated into the major cannabinoids: THC, CBC and CBD.
On the other hand, hemp-derived products are high in CBDA and low in THCA. This makes hemp extracts an ideal option for those seeking the natural benefits of CBDA.
Cannabidiolic Acid History
CBDA was first isolated in 1965 by renowned Israeli scientist Raphael Mechoulam, who was the discoverer of THC and CBD in medical cannabis.
As we have already explained in detail in our review above, CBDA is the precursor to the active compound CBD and when CBDA is exposed to heat or light it is converted into CBD. What sets CBDA apart from other cannabinoids is its ability to interact with the serotonin 5-HT1A receptor.
Studies have shown that CBDA activates this receptor more strongly than other cannabinoids, which could mean that it may provide better therapeutic results. Unlike other cannabinoids, CBDA does not directly interact with CB1 and CB2 receptors, which are found in the central nervous system and immune system.
Instead, it inhibits an enzyme called Cox-2, which may explain why it can produce more potent anti-inflammatory effects than CBD.
What are the potential CBDA benefits and effects?
Research into the potential CBDA benefits and effects is still in its infancy, but there is now a growing body of evidence that suggests this cannabinoid may offer a range of health benefits.
Some of the potential CBDA benefits may include:
Pain management effects: CBDA may have powerful anti-inflammatory effects that could help manage pain and reduce inflammation in conditions such as arthritis and others.
Nausea and vomiting effects: CBDA can help reduce nausea and vomiting, making it a valuable tool for those undergoing chemotherapy or other treatments that can cause such side effects.
Anxiety and depression effects: CBDA can have a calming effect on the brain, which can make it a valuable tool for dealing with anxiety and depression.
Seizures and epilepsy effects: CBDA may have anticonvulsant effects, making it a promising tool for treating seizures and epilepsy.
Anti-inflammatory effects: CBDA has potent anti-inflammatory properties that make it a promising anti-inflammatory agent. It can help reduce inflammation associated with various conditions such as arthritis, Crohn’s disease, and other inflammatory bowel diseases.
Neuroprotective effects: CBDA may also have a neuroprotective effect, meaning it can help protect the brain from damage and degeneration. It may be particularly helpful in conditions such as Alzheimer’s and Parkinson’s disease.
CBDA’s affinity for serotonin receptors helps it influence all areas from mood to inflammation.
So far, the most promising benefits of CBDA include its antiseptic properties, anti-cancer effects, anti-inflammatory properties, and anxiolytic effects. Although research is ongoing and has not yet been tested on humans, early results suggest that CBDA has the potential to improve mental and physical well-being.
Decarboxylation is the process of heating CBDA to a certain temperature to remove the acidic group (COOH) from the molecule, resulting in the formation of CBD (cannabidiol). This process can occur naturally through exposure to heat and sunlight, or it can be achieved through controlled heating in an oven or other device.
Once CBDA has been decarboxylated into CBD, it becomes more bioavailable and can be more easily absorbed by the body. This is why CBD products are generally more popular than CBDA products.
However, some people prefer to use raw cannabis products that contain CBDA, as they believe that it may have unique properties that are lost during the decarboxylation process. Cannabidiolic acid (CBDA) is found in abundance in the flowers of fresh hemp plants.