terpenes and herbs

Terpenes were once thought to deliver nothing more than an enticing aroma to thousands of plants, from cannabis to conifers and lavender to lilacs. From an evolutionary perspective, terpenes help to protect plants from pests and predators with their intense fragrance. Within the past couple of decades, however, researchers have learned that terpenes offer medical benefits to all mammals that rival those of their chemical cousins the cannabinoids.

Explore the 6 major terpenes in our CBD Oils and Capsules

LINALOOL

Linalool is one of the most recognizable aromas of all the terpenes. Linalool is a common terpene found in cannabis but is also naturally occurring in many flowers and spice plants. Over 200 species of plants produce linalool, but it’s best known for giving lavender its distinctive flavor and aroma. Linalool is found mainly in the families Lamiaceae (mint and other herbs), Lauraceae (laurels, cinnamon, rosewood), and Rutaceae (citrus fruits), but also birch trees and other plants from tropical climate zones 1. It’s even been found in some fungi.

A natural relaxant, linalool is often used in aromatherapy as a sleep aid and has been utilized as a treatment for anxiety for thousands of years. Linalool exhibits calming and sedative effects when inhaled, along with lower aggression and higher social engagement. Linalool has been linked to a variety of health benefits2 including analgesic, anxiolytic, sedative, anti-inflammatory, anti-tumor, and antibacterial effects.

 

Linalool makes up a significant portion of lavender essential oil, which has reported anti-agitation and antidepressant effects3, most likely due to its activity on the NMDA receptor. Linalool is also crucial in the production of Vitamin E in the body.

 

Linalool is used as a scent in up to 80% of perfumed hygiene products and cleaning agents, including soaps, detergents, shampoos, and lotions. Linalool extract can be applied directly to the skin or inhaled.  Additionally, linalool is used by pest professionals as a flea, fruit fly, and cockroach insecticide and some mosquito-repellent products.

LINALOOL

THERAPEUTIC BENEFITS

ANALGESIC: PAIN RELIEF

ANTIDEPRESSANT: RELIEVES SYMPTOMS OF DEPRESSION

ANTI-EPILEPTIC: REDUCES SEIZURES AND CONVULSIONS

ANTI-INFLAMMATORY: REDUCES INFLAMMATION

ANTIPSYCHOTIC: TRANQUILIZING EFFECTS REDUCE SYMPTOMS OF PSYCHOSIS

ANXIOLYTIC: RELIEVES ANXIETY

SEDATIVE: PROMOTES SLEEP

ß-CARYOPHYLLENE

THERAPEUTIC BENEFITS

ANALGESIC: PAIN RELIEF
ANTIBACTERIAL: SLOWS AND COMBATS BACTERIAL GROWTH
ANTIDEPRESSANT: RELIEVES SYMPTOMS OF DEPRESSION
ANXIOLYTIC: HELPS RELIEVE ANXIETY
ANTI-INFLAMMATORY: REDUCES SYSTEMIC INFLAMMATION
ANTI-PROLIFERATIVE: INHIBITS CANCER CELL GROWTH
ANTIOXIDANT: PREVENT OXIDATION DAMAGE TO MOLECULES AND CELLS IN THE HUMAN BODY
NEUROPROTECTIVE: SLOWS DAMAGE TO THE NERVOUS SYSTEM & BRAIN

ß-CARYOPHYLLENE

β-caryophyllene (BCP), an ancient remedy to treat pain, is a sesquiterpene found in large amounts in the essential oils of various spice and food plants such as copaiba, lavender, allspice, fig, roman chamomile, cloves, hops, oregano, cinnamon, and black pepper. This special component of the cannabis plant was first discovered in 1964 by pioneering Israeli academic researcher Raphael Mechoulam, who identified it as a terpene. It wasn’t until 2008 that a study by a group of German scientists observed the rare behavior and characteristics that indicated that BCP can also be labeled a cannabinoid.

 

It binds to the CB2 receptor, acting as a full agonist. This has several beneficial effects, one of which is to increase production and availability of the internally produced endocannabinoid anandamide. Anandamide is a beneficial cannabinoid that plays a critical role in the management of anxiety, appetite, depression, sleep, and pain and is sometimes referred to as the “bliss molecule.”

Typically, when a terpene is combined with CBD, the terpene contributes to what is known as the entourage effect, which enhances the therapeutic and quality of experience that a consumer might have. ß-caryophyllene is unique because it is a terpene possessing its own therapeutic qualities while activating the ECS without the addition of CBD.

ß-caryophyllene is widely recognized for its use in both acute and debilitating states of pain relief, but also has applications for immune system enhancement,4 stress and anxiety reduction,5 and anti-inflammation. It also has been found to promote healthy gut and digestion by protecting the cells that line the digestive tract.

 

 

Because it is so frequently encountered in foods, it is one of the few terpenes that the FDA recognizes as “safe” to consume in large doses.6

ALPHA-PINENE

Pinene, one of the most researched and documented terpenes found in cannabis, is available in two varieties: Alpha-pinene (sometimes denoted as α-pinene) and beta-pinene (β-pinene).

α-pinene is the primary terpene found in pine trees which gives them their characteristic “piney fresh” scent. While α-pinene is the most familiar and commonly found terpene in nature and is found in pine and conifer trees, rosemary, and orange peels, β-pinene is responsible for the more earthy aromas such as those found in basil, dill, parsley, and hops.

α-pinene is also a critical component in priming the human body to receive the healing benefits of CBD8 through the endocannabinoid system. So when α-pinene is used in tandem with high-quality CBD products, the “entourage effect” indicates some highly powerful medicinal uses. 9

Because α-pinene can cross the blood-brain barrier -– the mechanism that protects the brain from most substances that disturb neural function and brain composition -– α-pinene has been found to improve cognitive function and memory, increase focus and alertness, and reduce anxiety. It also has many promising uses in patients with Alzheimer’s and other neurodegenerative disease (Parkinson’s disease, Huntington’s disease, multiple sclerosis, etc.).

 

2011 study conducted by Russo and published in the British Journal of Pharmacology noted the anti-inflammatory properties of alpha-pinene and potential efficacy for inflammation-based patients, including those suffering arthritis, cancer, and Crohn’s. “It is anti‐inflammatory and is a bronchodilator in humans at low exposure levels,” reported the researchers, adding “Beyond this, it seems to be a broad‐spectrum antibiotic.”

ALPHA-PINENE

THERAPEUTIC BENEFITS

ANALGESIC: RELIEVES PAIN
ANTIBACTERIAL: SLOWS BACTERIAL GROWTH
ANTI-INFLAMMATORY: REDUCES INFLAMMATION SYSTEMICALLY
ANTI-PROLIFERATIVE: INHIBITS CANCER CELL GROWTH
ANTIOXIDANT: PREVENTS OXIDATION DAMAGE TO OTHER MOLECULES IN THE BODY

terpenes

THERAPEUTIC BENEFITS

ANALGESIC: RELIEVES PAIN
ANTIBACTERIAL: SLOWS BACTERIAL GROWTH
ANTI-DIABETIC: HELPS MITIGATE THE EFFECTS OF DIABETES
ANTI-INFLAMMATORY: REDUCES INFLAMMATION SYSTEMICALLY
ANTI-INSOMNIA: AIDS WITH SLEEP
ANTI-PROLIFERATIVE/ANTI-MUTAGENIC: INHIBITS CELL MUTATION, INCLUDING CANCER CELLS
ANTIPSYCHOTIC: TRANQUILIZING EFFECTS RELIEVE SYMPTOMS OF PSYCHOSIS
ANTISPASMODIC: SUPPRESSES MUSCLE SPASMS

MYRCENE

Myrcene was discovered to be the most abundant terpene in many cannabis strains. Myrcene is a monoterpene, the smallest of terpenes, and is found in very high concentrations in sweet basil, hops, mangos, and cannabis. It gets its name from Myrcia sphaerocarpa, a medicinal shrub from Brazil high in myrcene. In terms of aroma, this molecule produces an earthy, spicy, clove fragrance in the strains of cannabis in which it dominates. Myrcene’s major effect is sedative in nature, resulting in relaxed muscles and a reduction of pain. It is also used to treat insomnia. Myrcene is a recognized sedative as part of hops preparations (Humulus lupulus), employed to aid sleep in Germany (Bisset and Wichtl, 2004).

Myrcene has been found to block the cancer-causing effects of aflatoxins travel to many of our food sources from fungi. 12 Myrcene’s inhibition of the liver enzyme CYP2B1 is responsible for these anti-mutagen effects. It also mitigates DNA damage from toxins such as t-butyl-hydroperoxide. 13 Myrcene has also been used for many years as a folk remedy for hypertension, diabetes, diarrhea, and dysentery.

LIMONENE

Limonene, a cyclic monoterpene, has a pungent citrusy, bitter odor and flavor. Unsurprisingly, limonene’s highest concentrations are found in citrus fruits. Limonene also occurs naturally in a variety of other trees and herbs including pine, rosemary, mint, fennel, and juniper.

A terpene with a broad range of uses, limonene is commonly used in perfumes, household cleaners, food, and medicines. Limonene’s widespread use is largely due to its very low toxicity.

Like other terpenes, limonene conveys many medicinal benefits, including improvements in digestion, mood enhancement (helpful in the treatment of anxiety and depression), and significant anti-inflammatory properties. It is these anti-inflammatory characteristics that give limonene special value for hundreds of diseases and conditions related to inflammation, including cancer, arthritis, and asthma.

In addition, limonene has been found to aid in combating acid reflux (including heartburn) and decreasing anxiety. This valuable terpene has also been shown to dissolve gallstones and is a mild appetite suppressant. Limonene also has been established as an antimicrobial, antibacterial,16 antioxidant agent, and potentially contains numerous other health benefits.

LIMONENE

THERAPEUTIC BENEFITS

ANTIBACTERIAL: SLOWS BACTERIAL GROWTH
ANTIMICROBIAL: DESTROYING OR INHIBITING THE GROWTH OF MICROORGANISMS
ANTIFUNGAL: INHIBITS THE GROWTH OF FUNGUS
ANTI-INFLAMMATORY: REDUCES INFLAMMATION
ANTI-PROLIFERATIVE: INHIBITS CANCER CELL GROWTH
ANXIOLYTIC: RELIEVES ANXIETY
GASTRO-ESOPHAGEAL REFLUX: REDUCES ACID REFLUX
IMMUNOSTIMULANT: STIMULATES THE IMMUNE SYSTEM

TERPINOLENE

THERAPEUTIC BENEFITS

ANTIBACTERIAL: SLOWS BACTERIAL GROWTH
ANTI-FUNGAL: INHIBITS THE GROWTH OF FUNGUS
ANTI-INSOMNIA: AIDS WITH SLEEP
ANTI-PROLIFERATIVE: INHIBITS CANCER CELL GROWTH
ANTIOXIDANT: PREVENTS OXIDATION DAMAGE TO OTHER MOLECULES IN THE BODY

TERPINOLENE

Terpinolene is one of the many terpenes in the terpinene and pinene family. While they all share the same molecular formula, weight, and construction, the placement of the double carbon bond differentiates them. This defines their unique synergistic qualities when combined with CBD products for therapeutic benefits. 21

Terpinolene is found in oregano, marjoram, cumin, lilac, some citrus rind and conifers.

Terpinolene is popular in the scientific community for its antioxidant, 22 antibacterial,23 and antimicrobial24 properties in addition to the growing evidence for potential use in fighting cancer,25 treating anxiety, and improving cholesterol levels. Terpinolene also has notable sedative and sleep aid qualities.

Sources:

  1. https://pubchem.ncbi.nlm.nih.gov/compound/Linaloo

  2. https://www.ncbi.nlm.nih.gov/pubmed/26983194

  3. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5437114/

  4. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2449371/

  5. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4789136/

  6. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2768535/

  7. https://www.sciencedirect.com/science/article/abs/pii/S0031938414003400

  8. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4234427/

  9. https://bpspubs.onlinelibrary.wiley.com/doi/full/10.1111/j.1476-5381.2011.01238.x

  10. https://www.ncbi.nlm.nih.gov/pubmed/12122569

  11. https://link.springer.com/article/10.2478/s11756-013-0230-2#page-1

  12. https://www.steephill.com/science/terpenes

  13. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3165946/

  14. https://www.sciencedirect.com/science/article/pii/S0378427497000349

  15. https://www.sciencedirect.com/science/article/pii/S0278691508006492?via%3Dihub

  16. https://www.ncbi.nlm.nih.gov/pubmed/30508582

  17. https://www.ncbi.nlm.nih.gov/pubmed/25896273

  18. https://www.ncbi.nlm.nih.gov/pubmed/27888114

  19. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3598547/

  20. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5894671/

  21. https://www.ncbi.nlm.nih.gov/pubmed/16008117

  22. https://www.ncbi.nlm.nih.gov/pubmed/25372394

  23. https://www.ncbi.nlm.nih.gov/pubmed/21425693

  24. https://www.ncbi.nlm.nih.gov/pubmed/22740904

  25. http://europepmc.org/abstract/MED/23339024

Whether you are just hearing about it or have been following it for some time, CBD is gaining momentum as a novel treatment to several challenging ailments. Backed by scientific research and reliable sources, we are here to tell you everything you need to know about CBD to stay in the loop.

If you are interested in learning about or trying CBD, we will answer any questions or concerns you might have about this exciting molecule. From its available products to its possible health benefits to whether or not it is safe, this is your ultimate guide to CBD.

What is CBD?

Cannabidiol, famously known as CBD, is becoming a common treatment option for many diseases. It is one of many chemical compounds that you would find in the cannabis sativa plant. It is usually derived from the hemp plant in specific.

Contrary to the marijuana plant which can get you high due to the presence of the THC compound, CBD does not get you high. Hemp, on the other hand, contains very little amounts of THC so the extracted CBD has all the health benefits without any of the psychoactive ingredients.

That’s why, people struggling with chronic pain or other uncomfortable conditions have been turning to CBD for some relief without any intoxication.

cannadoca oil sample

How Does CBD Work?

In order to find out how CBD works, we need to have an understanding of the endocannabinoid system. The answer is between its three components which are the receptors, the enzymes, and the endocannabinoids so let’s examine them.

Receptors

These proteins exist all over our bodies and they bind to different components to cause reactions in our immunity systems. In this case, they bind to endocannabinoids. CB1 receptors are the ones who pretty much rule the central nervous system. They manage things like coordination, mobility, pain, appetite, memory, mood, and others in our body. The CB2 receptors, on the other hand, are found in the peripheral nervous system and play a role in pain and inflammation.

Receptor CB1

Receptor CB2

Enzymes

These components come in various forms but two types in specific break down endocannabinoids.

Endocannabinoids

These molecules are made by our bodies to keep our internal functions properly running.

All these different components of the endocannabinoid system work together naturally in our bodies all the time. The enzymes work to break down the cannabinoids. Later, the endocannabinoids try to bind with receptors. As far as we understand, CBD has some kind of influence over the receptor but does not completely bind to it. This influence is behind a lot of the positive effects CBD has on our bodies.

The Health Benefits Behind CBD Oil

There are some studies worth mentioning that give us a glimpse of what we can expect from the natural drug.

Anxiety and Mental Health

A lot of people may question the therapeutic effects of CBD on people suffering from mental health issues due to the remaining stigma surrounding these kinds of drugs. This concern is not totally without grounds since health care professionals do advise against using cannabis as a treatment for anxiety or stress.

This is because the THC compound found within cannabis can do more harm than good in this case. Some people with chronic anxiety have reported feeling even more anxious and sometimes paranoid under the influence of THC.

But this does not apply to CBD. People who use CBD oil or other CBD related products have actually found that it helps them manage their anxiety. A study conducted in 2019 reveals that CBD considerably decreased symptoms of anxiety in mice.

We keep unraveling more and more about CBD and the fact that it can help other anxiety disorders as well. A 2015 review suggests that people suffering from mental conditions including PTSD, social anxiety disorder, obsessive-compulsive disorder, and general anxiety disorder can greatly benefit from the extraordinary effects of CBD.

Pain and Inflammation

The Cannabis Sativa plant in general has been utilized for medicinal purposes for millennia all over the world. Many civilizations throughout history have recorded their use of the plant for a range of ailments ranging from joint pain and muscular spasms to gout and malaria, beginning with the Chinese as early as 2900 B.C.

This is incredibly astonishing since many people today say that CBD has helped them with a variety of other health issues that include chronic musculoskeletal or nerve pain. More and more studies are showing that by influencing certain receptors, CBD is able to suppress a lot of long term pain caused by chronic conditions.

CBD decreases inflammation by blocking the release of substances that cause inflammation in the body, according to mouse experiments conducted in 2018. These anti-inflammatory properties make it incredibly valuable in a number of ways. For example, a study shows that CBD has the capacity to protect against inflammation-induced vascular damage. So not only can CBD help your heart but it can also greatly improve inflammatory skin conditions like acne.

Skin Care and Health

CBD is remarkably diverse with therapeutic powers that span across every system in our bodies. Recently, there have been more and more sources validating the efficiency of CBD in the field of dermatology. By introducing topical CBD options like face creams or serums, we can provide a safer and perhaps more beneficial treatment to some of the most challenging skin diseases.

People suffering from uncomfortable skin diseases that cause inflammation, pain, redness, itchiness, and anxiety often inquire about CBD products to help them find some relief. Even challenging ailments like acne have shown promising results with CBD. The American Academy of Dermatology has advised utilising topical CBD products as an additional treatment for acne, eczema, and psoriasis.

CBD has an anti-inflammatory, anti-proliferative, and sebostatic impact on human sebocytes. These features demonstrate an encouraging start for a potential anti-acne treatment. It can be an option to relieve the pain and irritation without resorting to traditional drugs that have negative side effects.

Patients with the condition epidermolysis bullosa (EBS) who were treated with topical CBD expressed less discomfort, pain, and blistering. Not only that, they also showed quicker healing to their wounds and scars according to research. So there is hope on multiple fronts.

Results with Epilepsy

CBD is sought after for a number of health conditions. It is in wide demand for the relief of chronic pain resulting from Cancer, Arthritis, and so much more. But not a lot of studies have been made to confirm its wide ranging health benefits. So far, the most comprehensive research supports its efficacy in combating some of the toughest pediatric epilepsy syndromes, such as Dravet syndrome and Lennox-Gastaut syndrome (LGS).

These conditions do not usually respond to anti-seizure drugs but CBD has been shown in several trials to decrease the frequency of seizures and, in several cases, to completely suppress them. Epidiolex, which contains CBD, was recently licensed by the FDA as the first cannabis-derived drug for these disorders.

In the Epidiolex trials done to find out whether using CBD would be deemed safe or not for long term use, some side effects have been found. Diarrhea, sleepiness, nausea, exhaustion, rash, reduced appetite, and elevated liver enzymes were all recorded as side effects.

Battle Against Cancer

Cancer still remains one of the deadliest diseases known to man. Unfortunately, it is still, in some cases, incurable. But there are studies out there that offer promising data when it comes to cancer’s response to CBD.

It may seem like science fiction that there is something actually capable of slowing down cancer but data does not lie. A 2012 review described CBD as a possible ‘anticancer drug’. It provides evidence that cannabidiol suppresses the growth of some types of cancer and prevents their migration to other parts of the body. More research suggests that CBD may decrease the anxiety of people suffering cancer, enhance the effects of chemotherapy, and even diminish its harsh side effects. A 2020 review talks about the influence of CBD on breast cancer treatment in specific. It suggests combining CBD with the chemotherapy treatment plan to boost the immune system’s response and increase the treatment’s efficiency.

How to Use CBD?

All of these health benefits and others more that we are still finding out make a compelling argument in favor of CBD. There are so many kinds out there that you will even find options for your pet. Yep, CBD for cats exists. However, for human consumption, you might want to identify which kind matches your needs best so you get the most out of your experience.
So whether you have decided to give it a try or not, here is some crucial information to know about the types of CBD products out there and how you can use them.

Broad Spectrum CBD Oil

These proteins exist all over our bodies and they bind to different components to cause reactions in our immunity systems. In this case, they bind to endocannabinoids. CB1 receptors are the ones who pretty much rule the central nervous system. They manage things like coordination, mobility, pain, appetite, memory, mood, and others in our body. The CB2 receptors, on the other hand, are found in the peripheral nervous system and play a role in pain and inflammation.

ultimate guide to cbd
ultimate guide to cbd

Full Spectrum CBD Oil

This kind of CBD product is derived from the entire cannabis plant together with all of its natural components including THC, all other cannabinoids, terpenes, and essential oils. That is why you may sometimes find it referred to as “whole-plant CBD.” The entourage effect suggests that more cannabinoids working together is better than just one. So if you are looking to get the most benefit out of your dose, you might want to consider the full spectrum option.

CBD Oil Capsules

CBD capsules are a fantastic alternative for those who want the health benefits without any of the specific flavour of CBD oil. Its earthy taste can be enjoyable to some people or unpleasant to others. In that case, the capsules are the answer. Some CBD capsules even have other vitamins and nutrients alongside its CBD concentration so you get extra benefits. There are CBD capsules out there with the option of added vitamin B for example.

Hemp seed oil capsules
CBD face cream woman

CBD creams and topicals

There are a variety of skin care products that contain CBD such as face creams, face serums, and foot creams. They don’t just help you relax but they also offer great results. You apply it to your skin, massage it in, and await its impressive results which obviously vary depending on what you are using it for. CBD topicals usually relieve pain pretty quickly but other conditions may take longer to show effects.

Are There Any Side Effects?

CBD has been widely proven as safe and beneficial for regular use. Not only does it have minimal to none side effects, it can actually be a more effective neuroprotective antioxidant than vitamin C and E.

While it is typically considered harmless, some people may experience negative side effects. Symptoms such as diarrhea, fatigue, and changes in appetite have been previously reported.

That’s why it is so important to consult a doctor before using CBD. This will ensure it doesn’t interact with any medication you are on. It will also help you manage any side effects that may arise.

In Conclusion

CBD oil has been researched for its possible powers in relieving and perhaps eliminating altogether the symptoms of a variety of common health problems. It can help so many people with chronic conditions that make their life harder on a daily basis including depression, anxiety, and acne.

It can give cancer patients an alternative treatment with no side effects to manage their symptoms. Although there is still a lot to learn about CBD, what we have so far can point us down a promising road in treating heart disease, cancer, and more.

CBD oil is still being studied for its possible health advantages but it gives us nuanced hope in improving our day-to-day quality of life through a more natural approach.

Our mental and physical health rely on a number of complex systems in order to achieve balance. Most of these systems span our entire body. The endocannabinoid system (ECS) is one of the most important systems in many living organisms, from plants to humans.

Whenever there is imbalance in our body, the endocannabinoid system’s job is to relay this information to the brain, then relay instructions to our tissues and organs telling them how to restore balance. Before we get into the details it’s important that we understand the concept of “homeostasis”.

Homeostasis, comes from Greek for “remaining the same.” The term is commonly used in medicine to refer to a set of processes by which a living organism maintains a steady internal chemical and physical environment.

What is the Endocannabinoid System?

The Endocannabinoid system (ECS) is made of a group of neurotransmitters called endocannabinoids, that bind to cannabinoid receptors located all over the central and peripheral nervous system. Once activated, cannabinoid receptors causing changes in electrical impulses fired by nerve cells.

People have been using cannabis for thousands of years. It is only in the early 1940s that scientists were able to isolate the first cannabinoids from marijuana. In the 60s scientists identified the first cannabinoid receptor in our brain. We were then able to explain the “high” associated with marijuana intake as an interaction between cannabinoids from the plant and the receptors in our brain. However, it would be extremely reductive and false to say that this is the main function of these cannabinoid receptors.

In the early 90s scientists discovered the first naturally occurring cannabinoids and dubbed them “endo-cannabinoids”. We have receptors for these plant cannabinoids and they are able to influence us because our bodies naturally produce similar chemicals (endocannabinoids) that interact with these receptors to tip one side of the equation and restore balance. When we consume THC, we activate cannabinoid receptors and deliberately cause a temporary imbalance, also known as the “high”.

The ECS is basically a communication system. As we’ll discuss below, endocannabinoids act as messages that have a unique shape. This shape is recognized only by cannabinoid receptors throughout the body. Once the receptors are activated or inhibited by a certain endocannabinoid, they tell the cell they’re on to behave in a certain way. Since these receptors are so widespread in our bodies, they essentially affect every aspect of our life experience.

Let’s dive in!

Cannabinoid Receptors

If the ECS is a communication system where endocannabinoids are the message, then cannabinoid receptors are the receivers. They’re fixed molecules sitting on the outside of cells, and are compatible with certain cannabinoids. According to the location and type of cell they’re on, they can then trigger the cell to respond in a certain way.

The number of cannabinoid receptors is the limiting factor in the ECS. That simply means that normally endocannabinoids are always there and it’s the receptors that fluctuate in number. When a cell is under stressful conditions it senses this and produces more receivers to catch more messages. This process is called “upregulation”.

Alternatively, if the cell is receiving too much of these messages, it will “downregulate” receptor production. This pattern can be seen very clearly in THC tolerance. When THC levels are too much over a long time, the cells fight this overstimulation by reducing the number of receptors.

There is still plenty of research in the field, but we have conclusively identified two main cannabinoid receptors:
CB1 receptors: Mostly in the central nervous system (including the brain)
CB2 receptors: Located more peripherally

CB1 Receptor

Cannabinoid receptors type 1 (CB1) are located throughout the central and peripheral nervous system. However, lower concentrations are found in other tissues and organs as well. Usually, they sit on the surface of nerve cells.

Unlike most neuronal receptors, CB1 receptors cause the nervous system to relax when activated by cannabinoids. Activating these receptors initiates a cascade of reactions that eventually slow down the fiery messages that are usually passed through the nerve cells. It is for these reasons that cannabis has a famously relaxing effect.

endocannabinoid system human body

CB2 Receptor

CB2 receptors are typically found in immunological organs and immunological cells, where they aid in the coordination of responses to infection, damage, and other functions that maintain the body healthy and disease-free. The CB2 receptor has recently been discovered to play a function in inflammatory response as well as pain perceptions. The CB2 receptor, like the CB1 receptor during pain stages, rises in concentration in sites of tissue inflammation. The CB2 receptor is hypothesized to be an immune system regulator.

Endocannabinoids

The term “endo” comes from “endogenous” and it means that these are cannabinoids (mostly associated with cannabis) but they are naturally available in our bodies and carry out an important function.

Endocannabinoids are synthesized from fatty acids in our diet. Omega-6 fatty acids and omega-3 acids, are great raw materials for your body to make endocannabinoids. Foods like fish, nuts, and seeds contain these fatty acids in high proportions.

The two most well researched endocannabinoids are Anandamide and 2-Arachidonoylglycerol (2-AG).

Anandamide

Another famous endocannabinoid is 2-Arachidonoylglycerol (2-AG). It acts on nerve cells by regulating intracellular calcium levels, which in turn affects neuron firing. Research suggests that 2-AG is critical for regulating seizures. It does this by obstructing the nervous system from becoming too stimulated. It also has a role in keeping the heart healthy. By eliminating plaque buildup in the veins and arteries. It also influences feelings of hunger and regulates various other important physiological processes.

How Does the Endocannabinoid System Affect the Body?

For a synchronized mind-body connection, it’s important to look after your endocannabinoid system. The function of this system is to preserve and control homeostasis. Homeostasis is responsible for keeping balance in the body. The endocannabinoid system regulates homeostasis. It does this by aiding the body and brain in accepting change and responding. Sometimes called a bridge between the body and the mind. The system collaborates with all the organs. With the immune system, hormonal system, and nervous system whenever it faces stress.

It is what aids us in engaging with the environment around us. The human body is always in an interchange with its surroundings, maintaining and adapting to new stressors and inputs. But stress is something different. It is what promotes a protective response in nature. These can include all such activities that can occur in daily life. So, the purpose of the endocannabinoid system is to help your body run smoothly even in stressful conditions.

It is clear that the endocannabinoid system has a wide effect all through the body. Almost all types of vital sensations in the body are in some way or the other influenced by the ECS. For example, it plays a part in regulating sleep, metabolism, hunger, mood, coordination, immune system, reproductive organs, as well as, pleasure, pain and reward systems, and much more.

Phyto-cannabinoids

Unlike endocannabinoids, some molecules acting on the same CB1 and CB2 receptors can be taken from outside the body. The term “Phyto” in Phyto cannabinoids means that they’re from a plant origin, usually from cannabis and hemp.

THC

THC mimics the effects of anandamide. It goes right into similar receptors. But THC works like a supercharged version of anandamide. It over activates all the connecting systems to create that all too familiar, high feeling. But it is also linked with some side effects such as anxiety, especially when taken in high doses.

CBD

CBD has a different connection with the receptors.

Do you know the difference between Full Spectrum CBD oil, Broad Spectrum and CBD Isolate?

It seems to change the way that other cannabinoids interact with the receptor. For example, CBD seems to force anandamide to hold on to the receptor for a longer time, rather than directly activate the receptor. This is why you can’t get high off CBD alone, and why it’s deemed harmless. It’s also responsible for blunting the side effects of THC when taken together as it lets your endogenous cannabinoids compete with THC over the receptors. CBD is also known to better target CB2 receptors, leading to its popular use as an anti-inflammatory.

Full Spectrum CBD oil, CBD Isolate and Broad Spectrum CBD oil are three common labels that have important differences.

How do you know which CBD product is right for you?

CBD has become popular in recent years, with the CBD industry teeming with promises, terminology, and related products. With all these options out there, do you know the difference between Full Spectrum and Broad Spectrum? Although the two differ in some ways, they also share similarities.

Here’s how to know what’s behind the label of your CBD oil

There are three main CBD product types that you can find:

Full spectrum CBD oil
Broad Spectrum CBD oil
Isolate CBD oil

Do you know which is best for you? Why should you care about Full and Broad Spectrum?

While they may be strikingly similar at first glance, their slight differences create a world of change for you, the user.

This brings us to the first point; the defining role of Full Spectrum.

Full Spectrum CBD - The Whole Package

So, what makes a CBD product Full Spectrum?

Full Spectrum is a natural plant extract without any additional modifications.

There are many naturally occurring compounds within the cannabis plant. A Full Spectrum CBD product allows you access to all of these and their potential benefits. These include essential oils, flavonoids, terpenes, cannabinoids, and other natural compounds.

In what has been dubbed the Entourage Effect, research shows that all these compounds work together to synergistically enhance each other’s effects. While Broad Spectrum contains most of these plant compounds, there is one critical difference, Broad Spectrum goes through an extra step in the production process to remove any THC.

Does that mean Full Spectrum Always Contains THC?

If a product is sourced from hemp, it will contain no more than 0.3% THC, certainly not enough to render any effects. With our patented process all Cannadoca products contain no THC.

How do you know if Full Spectrum contains THC?

However, many Full Spectrum products may have cannabinoid profiles with higher levels of THC- depending on whether it was sourced from hemp or not.

While the label will give you an indication, it is always best to do your research. A simple check on a product’s lab report will tell you all you need to know. If the company is cagey with their third-party lab reports, it’s best to leave it out of your cart and seek a brand that will proudly direct you to the reports.

What is Broad Spectrum CBD?

While Broad and Full Spectrum products share many similarities, the defining differences pertain to the product’s contents. Broad Spectrum CBD will contain almost the same profiles as its Full Spectrum counterpart, except for the THC cannabinoid.

Broad Spectrum extracts contain multiple naturally occurring phytochemicals, but the ratios will be altered. Although it boils down to the THC removal, it can also often involve a complete change of the terpene and cannabinoid profiles. Broad Spectrum is a great choice for countries like the UK, where the law does not permit THC at all.

The production process for both Broad and Full Spectrum products will be identical most of the time. The Broad Spectrum production process will go one step further to remove the THC or THCA from the plant extraction. This is typically done using a chromatography machine.

Differences Between Broad Spectrum and Full Spectrum CBD Oil

Full Spectrum extracts contain all natural occurring phytochemicals from the plant, while the isolate contains only the isolated CBD and all other cannabinoids being removed. Broad Spectrum is the so-called middle man as it is crafted by merging the isolated phytochemicals to mirror a full spectrum effect; sans the THC.

Broad Spectrum products have a great range in terms of their terpene and cannabinoid profiles. Some products will maintain the full phytochemical range except for THC while others will have significantly modified phytochemical profiles.

Always check the cannabinoid profiles by checking up on the third-party reports. These should be easy to locate on the brand’s product page or website.

Broad Spectrum Benefits

Broad Spectrum products are made with specific and intentional cannabinoid profiles. This consistency is impossible to mimic with Full spectrum extracts as a natural full spectrum will vary greatly from plant to plant.

That being said, it is incorrect to assume this makes Broad Spectrum superior. For some, just the way nature intended is a preferential option.

No matter your preferences, the essential bit in your decision-making process comes when checking up on the third-party lab reports. Natural Full Spectrum extracts can’t offer this as the hemp plant’s phytochemical profile will vary from one crop to the next.

Full Spectrum CBD oil vs. CBD isolate

The main difference between Full Spectrum CBD and CBD Isolate lies in the contents.

The Full Spectrum product will have most of the plant’s natural extracts, including terpenes and cannabinoids, and possibly even up to 0.3% THC. With the isolated CBD, you get a guarantee that nothing else except the CBD is in it as it is made from the CBD crystals. Once again, you should always check the lab reports to know the exact cannabinoid profiles that the product contains.

Choosing the Right CBD Product

Want to know whether to use a Broad Spectrum or Full Spectrum product? Ask yourself these questions:

Do you need to pass a THC test?

If you are subject to regular drug tests or you need to pass one, maybe it is a good idea to go with the broad spectrum cbd as it has 0% thc. Make sure you are aware of the type of drug test you need to undergo.

Are you sensitive to THC?

Some people are highly sensitive to the THC compound. If you are, or even if you just want to avoid THC, then use a Broad Spectrum product.

The Bottom Line

If you want to avoid THC but still want to have all the benefits of the cannabis plant in its natural glory (compounds, terpenes, flavonoids, and other cannabinoids) then opt for a broad spectrum product. However, if you don’t mind having THC in your product, then a full spectrum could be the right choice.

And remember, research the lab reports to know exactly what cannabinoids the products contain.

A lot of people are curious about CBD as an addition to their wellness routine. Did you know that the Cannabis Sativa plant, which CBD is derived from, has been used thousands of years ago in ancient civilizations for its therapeutic and medicinal properties? There is even belief that Cannabis was mentioned in the Old Testament as “kaneh-bosm”.

So it has been around for a while but we are now just beginning to scratch the surface of what it can potentially do. You are probably aware that it has some health benefits and we are here to help you further explore them.

According to the US National Library of Medicine, CBD, also known as Cannabidiol, is a chemical compound derived from the Cannabis Sativa plant, more famously known as marijuana or hemp.

It’s used as a more natural plant-based approach to relax or calm people suffering from stress, anxiety, and other conditions. The reason it has become so popular is because it is a more natural product. More and more people are turning away from conventional drugs due to their unbearable side effects or the fact that they fail to help them in the first place. In their struggle to find better alternatives, people are leaning more and more towards sustainable and organic substances like CBD.

You would most likely find it in oils and creams but it can also be ingested through tinctures or edibles. CBD is not psychoactive, unlike delta-9-tetrahydrocannabinol (THC) which is the main active ingredient of marijuana. That means CBD will not get you high or give off any feelings of euphoria.

A lot of people have trouble differentiating between cannabis, marijuana, and hemp. It can be confusing to find where CBD fits in this realm. Well, hemp and marijuana are the two main species of Cannabis sativa. They both contain CBD, but you would find more CBD and less THC in hemp than you would in marijuana.

But don’t be fooled by those hemp oil labels. When hemp oil is extracted from the plant’s seeds, it becomes rich in Omega 3 and Omega 6 without having any Cannabinoids. That’s why hemp oil is mostly used in the beauty industry particularly in moisturizing creams and oils.

What Are the Effects of CBD?

People may introduce CBD to their regime for a variety of reasons. That’s why its effects vary depending on each person’s health, lifestyle, and conditions.

Some people take CBD for a boost of energy and focus. Others take it to feel more relaxed and even help them get better sleep. It is generally recommended for people suffering from stress, anxiety, and chronic pain for some long term relief.

Even though it has garnered promising results with users, not enough research is out there to give us accurate insight into how it should affect our body. That’s why one should manage their expectations when first taking CBD and keep an open mind.

How Does CBD Work?

Many people are surprised to know that our bodies naturally contain cannabinoids. The interaction between cannabinoids with cannabinoid receptors, which are part of the body’s endocannabinoid system, is where the magic happens. The body creates two types of receptors:

CB1 receptors:

These are pretty much everywhere around the body but are especially abundant in the brain. They manage the most important processes around your body like movement, pain, mood, perception, appetite, and more.

CB2 receptors:

You will find these more around the immune system where they impact inflammation and pain.

CBD triggers them causing the body to develop its own cannabinoids (endocannabinoids). So CBD is your body’s special cannabinoids enhancer. Unlike THC, which binds with cannabinoid receptors more extensively, CBD does not seem to attach tightly to these receptors. Instead, it seems to work by binding to serotonin receptors, which affect pain, mood, and sleep.

What to Consider When Buying CBD?

There are multiple ways to take CBD but your choice of method should be based on your objectives and reasons you’re using it in the first place. Methods differ from one to another in dosage and duration.

Some people use CBD creams or ointments for their muscles, joints, and ligaments for a more specific and localised relief. On the contrary, Tinctures, which is liquid applied under the tongue, and edibles take a while to kick in but once they do, they can last for a few hours.

When purchasing the CBD itself, it’s essential to make sure it has been reviewed by a third-party for quality assurance. Since CBD is not yet controlled by the FDA, it is not uncommon to purchase CBD that has questionable potency. Not to mention that you might be buying CBD that has traces or subtle amounts of THC that may show up on drug tests. Almost 70% of CBD products are mislabeled or falsely advertised, according to a study.

What Are the Different Kinds of CBD Oil?

There is a variety of products to choose from when buying CBD oil for the first time so the choice may seem daunting. We are here to lay out all the facts so you buy the best kind for you.

Isolate CBD Oil

his kind only contains CBD, so you would not find any other cannabinoids or traces of THC.

Full-Spectrum CBD Oil

As the name suggests, this kind has everything. It contains all of the cannabinoids you would naturally find in the cannabis plant, including THC. So you would find proteins, fatty acids, chlorophyll, fiber, flavonoids, and terpenes in the full-spectrum kind.

Broad-Spectrum CBD Oil

This kind is recommended for people who want all of the health benefits of the cannabinoids without any THC. Broad-Spectrum has multiple cannabinoids that work together in harmony for a potent effect.

Research suggests that more cannabinoids working together is better than just one due to the entourage effect. So full-spectrum would give you the full unfiltered CBD oil effect. But your pick out of these different kinds should match your personal needs so the decision is yours.

There is a lot more to find out about CBD but the information we have now is quite promising. People looking to enhance their health and wellness routine can find real value in CBD oil. Like most organic and safe supplements, each person should expect results that are unique to them. We believe it is worth exploring, do you?

Miron (violet) glass: the perfect packaging you deserve

At Cannadoca, we always strive to offer our clients products with exceptional quality and traceability, with respect to ingredients, naturalness, potency, taste, storage life and other important criteria that should comply with our highest quality standards.

In doing so, we always keep the environment in focus.

We know that the farming and the final stages of manufacturing CBD cosmetics, plays an important role in developing benefits, purity and quality. Packing sensitive compounds, like CBD and other organic ingredients, is a process too many companies overlook.

As you already know, what makes us special is that we control the entire process from the seed to the final product.

So, why don't other CBD brands use Miron Glass if it's so beneficial?

Based on our research and work, there are mainly 2 reasons. First and foremost is the PRICE. Miron glass costs up to 4 times more than amber glass and up to 10 times more than plastic jars and bottles.

The second reason is the lack of research and extensive due diligence. Also the use of amber or transparent glass for cosmetic products, is well accepted so the incentive to provide high quality packaging glass is generally low.

During all these years, we at Cannadoca have conducted an in-depth research on every aspect of our product. Our team met and spoke with many chemists, bio-physicists and biologists researchers and PhDs.

Our mission is to deliver products to our customers in such a way that this specific quality is fully maintained over a long period of time. Similar packaging materials limit this requirement as they are not sufficiently capable of protecting sensitive products from quality-reducing lighting influences.

MIRON violet glass provides a unique protection maintaining the value of the products at the same high level over a long period of time.

miron glass
miron glass

Functionality of Miron violet glass

The sun emits visible and invisible light. The visible spectrum becomes discernable to our eyes when the white light is channeled through a glass prism. At the same time, the light also contains a part that is invisible to our eyes and lies in the radius of electromagnetic wavelengths of infrared and UV-A. The sunlight enables all plants to grow. If they continue to be exposed to the sun after reaching maturity, the effect of the light changes and accelerates the molecular decaying process. Miron violet glass works like a natural filter only allowing the entranced of the sunlight that protects and improves the quality of premium and sensitive substances.

There is a large spectrum of packaging materials available and most of them are permeable to visible light. The following graphics show to which degree the light can penetrate in different materials: Miron violet glass blocks the complete spectrum of visible light with the exception of violet, the spectral range of UV-A and infrared light. This unique combination offers optimal protection against the ageing processes that are released by visible light, thus lengthening the durability and effectiveness of the products.

miron glass

A 2016 study by various experts and institutions found evidence of reduced bacterial and antimicrobial action of ultraviolet light or blue-violet light. Research showed that there was a significant drop in contaminants and that the UV light had antibacterial capabilities.

There are different types of UV light and they are determined by their wavelengths. UVa has a wavelength between 400 nm to 320 nm, UVb between 320 nm to 290 nm, and UVc between 290 nm to 100 nm. In the study, they used 405 nm or UVa for testing antibacterial abilities.

Ultraviolet glass bottles allow 25% – 45% of UVa light to pass through, which explains how it can prevent contamination and bacterial growth. By allowing food and liquids “sunbathe” in UVa light, they will be exposed to high amounts of bio-energy in the safest way possible.

uv-light-lenght

Source: A New Proof of Concept in Bacterial Reduction: Antimicrobial Action of Violet-Blue Light (405 nm) in Ex Vivo Stored Plasma

Furthermore, light – and other environmental elements such as water and gases – can give life to even the smallest seed. However, it can also accelerate the growth and maturity of an organism until it decomposes. That is, once a plant or fruit reaches its mature state, the light will contribute to its aging process, thus accelerating its decomposition.

With the ability of blocking visible light, ultraviolet glass, can prolong the shelf life of the food you put in the container.

Ultraviolet light as a disinfectant. One of the various uses of ultraviolet light is water disinfection. Research shows that UV light can kill bacteria and other pathogens by destroying their ability to multiply.

UV light can penetrate the cell wall of the bacteria and cause its molecules to go haywire, which prevents the bacteria from splitting. UV light damages the nucleic acid of harmful pathogens by creating covalent bonds in its DNA. These bonds will prevent DNA replication, and when the bacterium tries to multiply, it will die. Tragic, right? But this protecting light does save you from a lot of dangerous microorganisms like E. coli, cholera, salmonella, poliovirus, hepatitis, and more.

As if that wasn’t enough, UV light can also help disinfect water.

If you care a lot about your environment, you’d definitely want to switch to UV glass bottles. You see, UV light can disinfect water without the potentially harmful chemicals, and without killing the beneficial minerals contained in water.

In fact, it’s one of the most effective and accepted water treatment methods.

Other uses of UV light

Aside from protecting your food and drinks, UV light also has other uses in different industries.

In dentistry, dentists use a dental equipment called dental curing light. The curing light emits an UV light to harden dental cement to hold the braces on the teeth. They also use the light to set tooth fillings made from UV-sensitive resin.

Miron Violet Glass is 100% recyclable!

Miron glass is fully recyclable. Please dispose of it as you would other colored glass. If you’ve ever seen and touched the Miron Glass, you know it’s beautiful. It would be a waste to throw these high quality bottles and jars in the trash. Why not consider reusing them? After the products run out, wash the bottle with hot soapy water and then let it dry.

It can be used as:

  1. Storage of essential oils, extracts and different dyes that you want to keep fresh and long-lasting.
  2. Great for storing dry herbs during the winter period, without loss of potency and quality.

Why we use MCT as carrier oil?

Coconut oil naturally excels as a carrier oil in a number of categories. It has little or no flavor, making it a great choice to make tinctures. Additionally, it is thinner than most oils, making it easy to dispense and measure.

Coconut oil has several characteristics, acting as a natural antifungal, anti-inflammatory and antibacterial.

However, the best part of coconut oil is its abundance of saturated fats, particularly medium chain triglycerides (MCT). Medium chain triglycerides are small fat molecules that are easily absorbed by the body, directly through the liver. Fractionated coconut oil is simply the coconut oil that had the longer fat molecules removed to isolate the medium chain triglycerides. For this reason, fractionated coconut oil is also known as MCT oil which is one of the best carrier oils for CBD.

Bioavailability matters

Bioavailability is the biggest concern when determining the best carrier oil. Bioavailability, in this case, refers to the proportion of CBD your body can process compared to what it takes. CBD’s bioavailability is largely determined by the types of fat molecules contained in the carrier oil. There are many different types of fat, and the way they vary on a molecular level, affects how well it can carry CBD into your system. Besides bioavailability, individual differences between oils such as flavor, consistency and cost may affect their viability as carrier oils.

mct oil
bottle-with-coconut-oil-coconuts-with-shadow

More bang for your buck?

When it comes to choosing the right CBD oil, keep always in mind what carrier oil is used. Most carrier oils used are extra virgin olive oil, hemp seed oil and MCT (Fractionated coconut oil).

The oil with the lowest bioavailability is the hemp seed oil.

Olive oil has better bioavailability compared to the hemp seed oil.

We don`t and won`t argue about its health benefits, which are clear.

However the carrier oil with the highest bioavailability is the MCT oil. The lack of LCT (Long Chain Triglycerides) in MCT is what makes the nutrients in the carrier oil more carriable in blood, and thereby highly bioavailable. The increased bio-availability is just one reason why we chose MCT as a carrier oil.

 

mct oil

In addition to better delivery, we chose MCT oil for its own health benefits as well.

Although we could use hemp seed oil (“hemp oil”) as a carrier, as it would be better to use more than one good thing, MCT oil has been shown to have different health benefits due to its ‘Medium Chain Triglycerides from where it gets its name.

MCTs have been shown to be thermogenic, with the ability to positively increase the metabolism, improving cognitive function of the brain, balancing hormones, increasing energy, improving gut function with the ability to combat harmful bacteria, viruses, fungi, and parasites, in addition to its antioxidant characteristics.

MCT oil is almost as good for us as the cannabinoids & terpenes themselves!

We find the health benefits of a MCT oil, along with its neutral taste, both are better than the earthy, hard-to-mask-taste of hemp oils, plus MCT oil helps cannabinoids from being metabolized fast, helping them to accelerate the effect of CBD and reach other areas of the body compared to other carrier oils.

Hemp seed oil

Hemp seed oil comes from the seeds of the hemp plant. There are virtually no cannabinoids or terpenes in these oils.

Hemp seed oil is popular and beneficial as a health supplement on its own. It’s rich in omega-3 and omega-6 fatty acids — which are widely known for their benefits on the brain, joints, skin and immune tissues. The oil even has the ideal 4:1 ratio of omega-6 to omega-3 fatty acids.

mct oil
mct oil

Olive oil

Olive oil predominantly consists of long-chain triglycerides (LCTs), which takes longer to break down but may increase the absorption efficiency of hemp extracts in the digestive tract. Olive oil as a carrier tends to have a slower start but lasts longer compared to the other 2 carrier oils discussed above.

Literature cited

Marie-Pierre St-Onge, Brian Mayrsohn,  Majella O’Keeffe, Harry R. Kissileff,  Arindam Roy Choudhury, and Blandine Laferrère: Impact of medium and long chain triglycerides consumption on appetite and food intake in overweight men
Zgair, A., Wong, J. C., Lee, J. B., Mistry, J., Sivak, O., Wasan, K. M., … & Gershkovich, P. (2016). Dietary fats and pharmaceutical lipid excipients increase systemic exposure to orally administered cannabis and cannabis-based medicines. American journal of translational research
Marie-Pierre St-Onge, PhD, Aubrey Bosarge, BA, Laura Lee T. Goree, RD, MSc, and Betty Darnell, RD: Medium Chain Triglyceride Oil Consumption as Part of a Weight Loss Diet Does Not Lead to an Adverse Metabolic Profile When Compared to Olive Oil
D. L. Ingle, A. Driedger,  author D. Nakhasi – Published 1999 – Chemistry-  Journal of Food Science: Dietary Energy Value of Medium‐chain Triglycerides 
The Lancet, Neurology: Mechanisms of action for the medium-chain triglyceride ketogenic diet in neurological and metabolic disorders
Jonathan Thevenet, Umberto De Marchi, Jaime Santo Domingo, Nicolas Christinat, Laurent Bultot, Gregory Lefebvre, Kei Sakamoto, Patrick Descombes, Mojgan Masoodi, Andreas Wiederkehr: Medium-chain fatty acids inhibit mitochondrial metabolism in astrocytes promoting astrocyte-neuron lactate and ketone body shuttle systems
Hiroyuki Takeuchi, Seiji Sekine, Keiichi Kojima, Toshiaki Aoyama:
The application of medium-chain fatty acids: edible oil with a suppressing effect on body fat accumulation

Why we choose sesame seed oil carrier?

One of the ways to bring the CBD in your body is by using carrier oil. CBD as you already know, is a fat soluble molecule. In nature, there are plenty of crops, vegetables and fruits rich in fats. A lot of them are used as carrier oils for different tinctures, extracts, cosmetics etc. One of the most popular carrier oils are made from sesame seeds, coconut, olives, hemp seeds, avocado, grape seeds, raspberry seeds, walnuts and others.

The body has two different ways for absorbing compounds, a water-soluble pathway and a fatsoluble pathway. CBD is a fat-soluble substance and thus can’t go directly to the bloodstream. We use the oil “ to carry” the CBD and other phytochemicals.

It is very important to get the most possible effect when consuming CBD and consider how to improve their bioavailability. In other words, , we care about the proportion of a substance that can have the maximum effect with the same amount in our systems after being introduced into our body.

When CBD is combined with a fatty vegetable oil, such as sesame oil or whatever, it binds directly to the fat molecules that our body is familiar with processing, strengthening CBD absorption and bioavailability.

Another benefit of using the carrier oil is that it makes measuring doses much easier and accurate.

Also, a very important aspect is that the carrier oils bring their own health benefits.

sesame seed oil
sesame-oil

Here is why we use Organic Sesame Indicum Oil:

Sesame is a plant cultivated for its edible seed, oil and flavorsome value. The Sesame seed is a reservoir of nutritional components with numerous beneficial effects along with health promotion in humans. The bioactive components present in the seed include vital minerals, vitamins and health compounds. It is called the “Queen of Oilseeds” due to its high degree of resistance to oxidation and rancidity.

sesame seed oil

Benefits of Adding Carrier Oils to CBD?

Let’s discover in details the three main reasons carrier oils are used.

Carrier Oils Enhance CBD Absorption

One of the main reasons CBD oil manufacturers dilute hemp extracts like CBD in a carrier oil is to improve absorption in the gut and the bioavailability..

Bioavailability is the proportion of a substance that can have an effect in your system after being introduced to the body in one form or another. In other words, it’s how much effect you’ll get from your CBD after consumption.

When anything is ingested, it moves through multiple organs, breaking down bit by bit along the way. If you ingest CBD oil, it travels to the stomach, then the small intestine, then through the metabolic system to your liver. The liver metabolizes the oil before it goes out into the circulatory system.

Fat-soluble substances , like CBD cannot enter the bloodstream directly. First, they need to get packaged up into tiny droplets called micelles. These micelles then enter the fatty lymph tissue — a network of fat-based compounds and immune cells. Then, they travel up the body through the lymph, eventually entering the bloodstream directly above the heart. In the diagram above, the lymph is the green tubes (called lacteals). These lacteals carry the CBD (and other cannabinoids) to the lymphatic system.

Absorbing fats in this way requires a series of enzymes in the digestive tract to prepare the fat molecules for absorption by breaking them down and turning them into micelles. When we eat fats, taste receptors in our mouth send signals to the digestive tract to get these enzymes ready.

sesame seed oil

Carrier Oils Make Measuring Doses Easier

For example, the difference between 5 mg and 50 mg of CBD extract is minuscule — 50 mg of this highly-refined source of CBD is about the size of a match head.

Getting precise doses like 7.5 mg requires a precision scale and can’t be done accurately with the naked eye or at home. We need special equipment for this, which simply isn’t realistic and extremely expensive for most CBD users.

The solution is to first dilute the extract (paste) into a carrier oil at a predictable amount —such as 300 mg, 500 mg, 1000 mg, or 1500 mg CBD per bottle like you’ll find listed on most CBD oils.

From here, a larger amount of oil with dissolved CBD is much easier and more accurate to measure. The same 50 mg dose can be measured by counting the drops of oil or measuring the fluid in a dosing syringe.

This makes CBD dosing significantly more accurate and consistent. In addition, it creates space for small dosing errors.

Carrier Oils May Offer Additional Health Benefits

Many carrier oils bring health benefits of their own.

For example, coconut oil is widely recognized for its antibacterial and antifungal properties and may help increase levels of HDL (“good”) cholesterol. Olive oil is reported to reduce the risk of heart disease in other ways.

Other carrier oils offer antioxidant benefits, provide a small amount of energy to the body, offeringomega-6 fatty acid and omega-3 fatty acid as well.

Sesame Oil

Sesame (Sesamum indicum L.) belonging to the order tubiflorae, family Pedaliaceae, is a herbaceous annual plant cultivated for its edible seed, oil and flavorsome value. It is also known as gingelly, til, benne seed and popularly as “Queen of Oilseeds” due to its high degree of resistance to oxidation and rancidity.

Sesame seed contains 50-60% of high quality oil which is rich in polyunsaturated fatty acids (PUFA) and natural antioxidants, sesamin, sesamolin and tocopherol homologues. These bioactive components enhance the stability and keeping quality of sesame oil along with numerous health benefits. Sesame seeds are considered as valuable foods as they enhance the diet with the pleasing aroma and flavor and offer nutritional and physiological benefits. Recent studies on the antioxidant and anti-carcinogenic activities of sesame seed, have greatly increased its applications in health food products that assert for liver and heart protection and tumor prevention. Sesame seed is high in protein, vitamin B1, dietary fiber as well as an excellent source of phosphorous, iron, magnesium calcium, manganese, copper and zinc. In addition to these important nutrients, sesame seeds contain two unique substances, sesamin and sesamolin. Both of these substances belong to a group of special beneficial fibers called lignans and have a cholesterol lowering effect in humans.

Sesame seeds composition

Sesame seed is rich in oil, contains high amounts of (83-90%) unsaturated fatty acids, mainly linoleic acid (37-47%), oleic acid (35-43%), palmitic (9-11%) and stearic acid (5-10%) with trace amount of linoleic acid.

Health benefits

Sesame seed oil have a wide pharmaceutical application and have played a prominent role in Chinese and Indian medicine for centuries.

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